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KMID : 0359919940130040917
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Korean Journal of Nephrology
1994 Volume.13 No. 4 p.917 ~ p.923
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A Case Report of Membranoproliferative Glomerulonephritis Associated with H-mole-
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정혜전
이태원/안재형/임천규/김명재/홍진기/양문호
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Abstract
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Renal disease with distinctive pathologic features was developed in a young woman with H-mole. The renal abnormalities were manifested by severe proteinuria and microscopic hematuria and the blood pressure was elevated.
Pathologic examination of the renal biopsy specimens showed distinctive glomerular abnormalities,d characterized mainly by diffuse increase of mesangial matrix and accentuation. Capillary walls were diffusely thickened and lumens were largely
obliterated. Trichrome stains revealed some subendothelial and meangial fuchsinophilic depostis. Ultrastructural study showed increased mesangial matrix and thickening of the capillary walls with mesangial interposition and a few small
subendothelial
electron dense deposits. Overlying epithelial foot processes were partially obliterated. These findings were consistent with membranoproliferative glomerulonephritis type I. The renal abnormaltities disappeared after suction curratage of H-mole.
The
clinical and pathologic features in this case suggest that the renal abnormalities were related to the uterine tumors and that the production of immune complexes and/or the activation of intravascular coagulation by the tumors may be the
pathogenetic
mechanisms.
We report a case of H-mole-associated membranoproliferative glomerulonephritis.
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KEYWORD
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